Introduction systemic lupus erythematosus sle is a chronic autoimmune disease of unknown cause that can affect virtually any organ of the body. Immunologic abnormalities, especially the production of a number of antinuclear antibodies ana, are a prominent feature of the disease. Sle is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. Although the term lupus erythematosus was introduced by 19thcentury physicians to describe skin lesions, it took almost 100 years to realize that the disease is systemic and spares no organ.
Dna area hallmark of lupus,and, together with othercellular andsoluble mediators of in. Sle affects many organ systems, including the central and peripheral nervous systems and muscles. The pathophysiology of systemic lupus erythematosus and. Pathophysiology is defined as the study the biological and physical manifestations of disease as the correlate with the underlying abnormalities and physiological.
Using the american college of rheumatology acr and systemic lupus international collaborating clinics slicc criteria to determine the diagnosis of systemic lupus erythematosus sle in patients with subacute cutaneous lupus erythematosus scle. Review this overview and discuss any symptoms you have with your doctor. The loss of tolerance with subsequent immune dysregulation is a consequence of genetic. It usually follows a chronic course and hence can also be termed as a chronic disease. Systemic lupus erythematosus rhode island medical society. The pathophysiology of systemic lupus erythematosus and the n ervous system 357 with the antiphospholipid antibodies. Learn the clinical presentation of lupus, including the genetic and environmental triggers, symptoms, cell damage and the bodys immune response.
Pdf the exact pathoaetiology of systemic lupus erythematosus sle remains elusive. The pathophysiology of sle is thought to involve an interplay between genetics monozygotic twins and epigenetics, immunology factors, hormonal factors such as oestrogen and environmental factors. Systemic lupus erythematosus sle, is the most common type of lupus. Dyskinesias may occur and the pathophysiology is thought to be due to the effects of the antiphospholip id antibodies. Although great strides are being made toward clarifying the immune dysregulation seen in sle, clinical disease expression is undoubtedly the end result of varied environmental and immunologic stimuli acting on a. Pathogenesis of human systemic lupus erythematosus cell press. The etiology of systemic lupus erythematosus sle remains unknown. Systemic lupus erythematosus sle is a systemic multisystem autoimmune disease characterized by the presence of autoantibodies and multiorgan system involvement. Some genes implicated in systemic lupus erythematosus sle and lupus nephritis might contribute to the pathology of disease by breaching. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. Systemic lupus erythematosus sle is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a. The pathophysiology of systemic lupus erythematosus includes the nervous system, digestion, heart, lungs, blood, muscles, bones, kidneys and skin.
Systemic lupus erythematosus sle is a chronic inflammatory disease of unknown cause that affects, either singularly or in combination, the skin, joints, kidneys, nervous system, and membranes lining body cavities and often other organs as well. Systemic lupus erythematosus lupus is a chronic longlasting autoimmune disease that can affect many parts of the body. Estimated incidence rates are 1 to 25 per 100,000 in north. Novel subsets of adaptive immune effectors, and the contributions of innate immune cells including platelets neutrophils, are being increasingly recognized in lupus pathogenesis.
Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. A complex interaction of genetics, environment, and hormones. Review pathogenesis of systemic lupus erythematosus. Anaemia is found in about 50% of patients, with anaemia of chronic disease being the most common form. Systemic lupus erythematosus sle linkedin slideshare. Introduction systemic lupus erythematosus is a chronic, multisystem, inflammatory, autoimmune disorder characterized by formation of autoantibodies directed against selfantigens and immunecomplex formation resulting in damage to essentially any organ. Sle is an autoimmune disease in which environmental triggers in genetically susceptible individuals results in the activation of the innate and adaptive immune response, leading to a loss of tolerance to ubiquitous selfantigens. Introduction systemic lupus erythematosus sle is a multi system connective tissue disorder characterized by the presence of. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. The pathoaetiology of systemic lupus erythematosus sle probably involves complicated and multifactorial interactions among various genetic and environmental factors multiple genes contribute to disease susceptibility, including genes encoding complement and other components of the immune response, in addition to major histocompatibility. It is more common in african americans and people of american indian and asian descent than in. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Genetics and pathogenesis of systemic lupus erythematosus and.
Systemic lupus erythematosus is a remarkable and challenging disorder. While systemic lupus can affect any area of the body, most people experience symptoms in only a few organs. There are various types of rashes in systemic lupus erythematosus sle, the. Systemic lupus erythematosus sle is a chronic autoimmune disease affecting multiple organs. Aberrant innate immune responses play a significant role in the pathogenesis of sle. A pathophysiologybased approach to the diagnosis and treatment. Systemic lupus erythematosus sle, or lupus is a systemic autoimmune disease with multiorgan inflammation. Systemic lupus erythematosus clinical presentation youtube. The exact pathoaetiology of systemic lupus erythematosus sle remains elusive. Read an overview of the pathophysiology of systemic lupus. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. This complex clinical presentation and pathogenesis makes.
Haematological abnormalities are common in systemic lupus erythematosus. Pathophysiology of demyelinating disease sle may cause changes in both cns and pns myelin. Pathogenesis of human systemic lupus erythematosus. Pdf pathogenesis of systemic lupus erythematosus researchgate. Systemic lupus erythematosus sle is a common autoimmune disease, with. Systemic lupus erythematosus sle signs and symptoms. Systemic lupus erythematosus sle, lupus is characterized by a. Patients with autoimmune haemolytic anaemia usually belong.
Pathogenesis of systemic lupus erythematosus c c mok, c s lau j clin pathol2003. Systemic lupus systemic lupus erythematosus a multisystem autoimmune disease etiology unknown most common in women, young to most common in women, young to middleaged highly variable clinical presentation highly variable clinical presentation in individual patients harvardmit division of health sciences and technology. Systemic lupus erythematosus has many guises, but the unifying feature is the presence of antibodies against doublestranded dna in almost all patients. Systemic lupus erythematosus overview the lupus initiative.
A patient who developed central retinal vein occlusion and blindness during. When you hear someone say that they have lupus, its likely that theyre referring to sle. It may involve only a single organ, but in its due course, it usually involves multiple organs of the body. Erythematosus pathogenesis of systemic lupus and their. This cpg on systemic lupus erythematosus sle is framed within this context. Pathogenesis of systemic lupus erythematosus journal of clinical. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The reported prevalence of systemic lupus erythematosus sle in the united states is 20 to 150 cases per 100,000.
Systemic lupus erythematosus an overview sciencedirect. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Sle manifestations are associated with multiple autoantibodies, ensuing immune complex formation and deposition, and other immune processes 2,3. Due to improved detection of mild disease, the incidence nearly tripled in the last 40 years of the 20 th century. Sle is a systemic autoimmune disease whose clinical manifestations, course and prognosis are very heterogeneous and require the involvement of a large number of specialists in the health care process. Studies have revealed metabolic cellu lar aberrations, which underwrite cell and organ injury, as important contri to lupus disease. Certain risk factors have been identified and shown to contribute to disease suscepti bility or activate the.
The pathogenesis of systemic lupus erythematosus an update. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably. Systemic lupus erythematosus sle is a complex autoimmune disease with variable clinical features 1,2. The signs and symptoms of sle vary among affected individuals, and can involve many organs and systems, including the skin, joints, kidneys, lungs, central nervous. Systemic lupus erythematosus sle is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. Retinal lesions occur in 25 to 30% of patients with systemic lupus erythematosus sle. It may affect virtually any organ or structure of the body, especially the skin, kidneys, joints, heart, gastrointestinal tract, brain, and serous membranes membranous linings of organs, joints, and cavities of the body. Pathogenesis 20 and clinical features 1 introduction systemic lupus erythematosus sle is the prototypic multisystem autoimmune disorder with a broad spectrum of clinical presentations encompassing almost all organs and tissues.
Lupus is an autoimmune disease, which means that the immune system erroneously acts against its own healthy tissues. Most people suffering from systemic lupus erythematosus will develop pain in their muscles, joints and peripheral joints such as joints. Pdf pathophysiology of sle find, read and cite all the research you need on researchgate. Pathophysiology of lupus pathophysiology of sle dr. Systemic lupus erythematosus sle is the most common type of lupus.
Clinical practice guideline on systemic lupus erythematosus. Clinical presentation, pathophysiology, and therapeutic strategies over the course of disease. An extremely complicated and multifactorial interaction among. Systemic lupus erythematosus sle is an autoimmune disease in which the bodys immune system attacks its own healthy tissue. More than 90% of cases of sle occur in women, frequently starting at childbearing age. It is one of the most frequent autoimmune diseases, with an. Systemic lupus erythematosus is the most common form of the disease. The most common issue for patients suffering from systemic lupus erythematosus is to do with their joints somers et al 2007. In women, prevalence rates vary from 164 white to 406 african american per 100,000. Systemic lupus erythematosus sle is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. Systemic lupus erythematosus genetics home reference nih. It should be considered as a potential diagnosis in all patients who present with multiorgan system disease.